Trials / Completed
CompletedNCT00214019
The Effect of Salmeterol on Eosinophil (EOS) Function
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 36 (actual)
- Sponsor
- University of Wisconsin, Madison · Academic / Other
- Sex
- All
- Age
- 18 Years – 55 Years
- Healthy volunteers
- Not accepted
Summary
This study is designed to test the hypothesis that salmeterol use, and not fluticasone use or the combination treatment with fluticasone and salmeterol, is associated with a greater number of sputum eosinophils following antigen challenge and, under these circumstances, the migrating peripheral blood eosinophils are less adherent.
Detailed description
An antigen challenge is when a participant inhales either cat, ragweed, or dust dander in increasing concentrations until their lung function drops 15 or 20 percent.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | salmeterol | salmeterol diskus 50 mcg twice per day |
| DRUG | Fluticasone | placebo diskus, fluticasone MDI 88 mcg twice per day |
| DRUG | Placebo | placebo diskus |
Timeline
- Start date
- 2003-11-01
- Primary completion
- 2008-01-01
- Completion
- 2008-01-01
- First posted
- 2005-09-21
- Last updated
- 2017-11-21
- Results posted
- 2016-08-08
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00214019. Inclusion in this directory is not an endorsement.