NCT00213915

L-arginine Supplementation and Exercise; L-arginine Supplementation and Renal Function

Effects of Oral Chronic L-arginine Supplementation on Exercise and Renal Function of Heart Transplant Recipients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (planned)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

* exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction * cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation * to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients

Conditions

• Heart Transplantation

Interventions

Type	Name	Description
DRUG	12 g of L-arginine glutamate during 6 weeks twice a day

Timeline

• Start date: 2004-02-01
• Completion: 2004-12-01
• First posted: 2005-09-21
• Last updated: 2025-12-22

Locations

3 sites across 1 country: France