NCT00213551

Glutamine and Intestinal Protein Metabolism

Comparative Effects of Glutamine and Glucose on Intestinal Protein Metabolism in Healthy Humans

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University Hospital, Rouen · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Gut barrier plays a major role in defence of the organism. During catabolic states, like major surgery or inflammation, gut barrier could be altered. It has been reported that preoperative nutritional support may have beneficial effects on clinical outcome in patients with surgery on gastrointestinal tract. Glutamine, which is a conditionally essential amino, have been reported to modulate inflammatory, antioxidant responses and protein metabolism in intestine. In addition, glutamine supply improves clinical outcome in critically ill patients. Antioxidant micronutrients may also have some beneficial effects in intestine by improving antioxidant response and might also regulate protein expression. Nevertheless, effects of glutamine combined to antioxidant micronutrients have not been evaluated. Thus, the aim of this study will be to assess the influence of glutamine and glutamine-antioxidant micronutrients-containing solutions on intestinal response in humans.

Conditions

• Healthy Volunteers

Interventions

Type	Name	Description
DRUG	Glutamine
DRUG	Glucose
DRUG	glutamine-antioxidants containing solution

Timeline

• Start date: 2004-04-01
• Completion: 2008-06-01
• First posted: 2005-09-21
• Last updated: 2013-06-18

Locations

1 site across 1 country: France