NCT00213525

Genesis of Scleroderma: Role of Environmental Factors in 100 Patients With Scleroderma and 300 Controls

Genesis of Scleroderma: Role of Environmental Factors in 100 Patients With Scleroderma and 300 Healthy Controls

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 300 (actual)
• Sponsor: University Hospital, Rouen · Academic / Other
• Sex: All
• Age: 18 Years – 76 Years
• Healthy volunteers: Accepted

Summary

Scleroderma is an autoimmune disease of unknown origin. Recently, the role of environmental factors, and particularly toxic drug exposure, in the genesis of scleroderma has been suggested. This prompted us to conduct this prospective, case-control, multicentric study, including 2 groups of subjects: * 100 patients with scleroderma * 300 sex- and age-matched healthy controls. The aim of our study is to determine whether exposure to toxics is higher in patients with scleroderma compared with healthy controls.

Detailed description

The data of patients with scleroderma and healthy controls will be compared regarding: * a standardized questionnaire about "cursus laboris" at initial inclusion * a search for toxics in blood, urine and hair: at initial exvaluation, 6 month and 2 year-follow-up

Conditions

• Scleroderma

Interventions

Type	Name	Description
OTHER	Questionnary for environmental factors research	Questionnary for environmental factors research

Timeline

• Start date: 2004-10-01
• Primary completion: 2008-10-01
• Completion: 2008-10-01
• First posted: 2005-09-21
• Last updated: 2015-02-05

Locations

1 site across 1 country: France