NCT00209859

Methotrexate and Cyclosporine in Treatment of Early Rheumatoid Arthritis

Combination Treatment With Methotrexate and Cyclosporine in Early Rheumatoid Arthritis.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 160 (planned)
• Sponsor: Hvidovre University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

To investigate whether cyclosporine, added to methotrexate and steroid, increases the possibility of inflammatory management early in the disease; furthermore to investigate the possible steroid-sparing effect of cyclosporine in patients with recently diagnosed rheumatoid arthritis.

Detailed description

Design: Multicentre, prospective, randomised, double-blind study with parallel design. Selection of patients: Patients with recently diagnosed rheumatoid arthritis (less than 6 months of persistent synovitis).

Conditions

• Rheumatoid Arthritis

Interventions

Type	Name	Description
DRUG	Methotrexate
DRUG	Intraarticular betamethasone
DRUG	Cyclosporine/placebo-cyclosporine

Timeline

• Start date: 1998-10-01
• Completion: 2007-11-01
• First posted: 2005-09-21
• Last updated: 2005-09-21

Locations

1 site across 1 country: Denmark