NCT00209495

Effect of Paracetamol,Pregabalin and Dexamethasone on Pain and Opioid Requirements in Postoperative Patients

Effect of Paracetamol Versus Paracetamol Combined With Pregabalin Versus Paracetamol Combined With Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients Scheduled for Abdominal Hysterectomy.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 130 (actual)
• Sponsor: Glostrup University Hospital, Copenhagen · Academic / Other
• Sex: Female
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Women scheduled for abdominal hysterectomy needs postoperative pain treatment, i.e. morphine. Unfortunately morphine has side-effect: nausea, vomiting, sedation and dizziness, which is unpleasant for the patients and sometimes keeps them at bed longer time than needed. We investigate in new combinations of analgesics for postoperative pain, hoping to minimize the need for morphine.

Detailed description

Combinations of paracetamol versus paracetamol + pregabalin versus paracetamol + pregabalin + dexamethasone is investigated. Primary outcome is 24 hours morphine usage.

Conditions

• Pain, Postoperative

Interventions

Type	Name	Description
DRUG	Pregabalin; Dexamethasone	Comparing combinations of paracetamol + pregabalin 300 mg + dexamethasone 8 mg

Timeline

• Start date: 2005-06-01
• Primary completion: 2007-11-01
• Completion: 2008-02-01
• First posted: 2005-09-21
• Last updated: 2008-02-29

Locations

2 sites across 1 country: Denmark