NCT00204451

Human Ovarian Follicular Dynamics and Emergency Contraception

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (planned)
• Sponsor: University of Saskatchewan · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The researchers hypothesize that emergency contraception (EC) will initiate the changes associated with atresia or ovulatory failure at all stages of follicular development and that the image attributes associated with atresia will be similar regardless of the diameter of the dominant follicle when ovarian suppression is initiated. Second, changes associated with atresia may be observed, but ovulation of the dominant follicle is unimpeded.

Detailed description

This study is a single-center, randomized, open-label, double-controlled protocol to study the pattern of ovarian follicular growth and regression in two groups of women. The first group will use Plan B, which is a progesterone only OC containing 0.75 levonorgestrel. The second group of women will use the Yuzpe regimen, which uses 50 mg ethinyl estradiol/0.5 mg levonorgestrel pills at different stages of the menstrual follicular cycle.

Conditions

• Contraception

Interventions

Type	Name	Description
DRUG	0.75 levonorgestrel
DRUG	50 mg ethinyl estradiol/0.5 mg levonorgestrel

Timeline

• Start date: 2005-07-01
• Completion: 2006-06-01
• First posted: 2005-09-20
• Last updated: 2016-11-28

Locations

1 site across 1 country: Canada