NCT00201253

Expression of Tuberculosis in the Lung

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: University of Medicine and Dentistry of New Jersey · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess lung immune responses in patients with active pulmonary tuberculosis (TB) and in healthy control persons who are exposed to Mycobacterium tuberculosis in households of patients with TB or who are unexposed.

Detailed description

BACKGROUND: M. tuberculosis infects a third of the world's population, and TB is the leading cause of morbidity and mortality due to a single infectious agent. However, only 5% to 10% of M. tuberculosis-infected subjects without an underlying immunodeficiency develop disease during their lifetimes. Therefore protective immunity is induced in the majority of subjects. Understanding correlates of protection against M. tuberculosis in humans is needed to better direct efforts in the development of antituberculosis vaccines. DESIGN NARRATIVE: Patients are treated according to good clinical practice; however, no study medications are given as part of the research study. This study involves a one-time bronchoalveolar lavage and venipuncture to obtain immune cells for laboratory studies of immune responses.

Conditions

• Tuberculosis

Interventions

Type	Name	Description
OTHER	Bronchoalveolar lavages and venipunctures only

Timeline

• Start date: 2000-09-01
• Primary completion: 2008-06-01
• Completion: 2008-06-01
• First posted: 2005-09-20
• Last updated: 2015-01-26

Locations

2 sites across 2 countries: United States, Mexico