NCT00199303

Efficacy of Pre- and Post-Operative Oral Dextromethorphan

Efficacy of Pre- and Post-Operative Oral Dextromethorphan for Reduction of Intra- and 24-Hr Post-Operative Morphine Consumption for Transabdominal Hysterectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (planned)
• Sponsor: Khon Kaen University · Academic / Other
• Sex: Female
• Age: 30 Years – 60 Years
• Healthy volunteers: Accepted

Summary

We studied the effect of dextromethorphan (DEX), an N-methyl-d-aspartate antagonist, on analgesic consumption and pain scoring after abdominal hysterectomy. Our aim was to compare the analgesic effectiveness and incidence of adverse side effects of oral DEX with placebo (P)

Detailed description

One hundred patients were randomized to two groups. Group DEX was given 30 mg tablets of oral dextromethorphan with their pre-medication and three more times in the first 24 hours after surgery. Group P received the placebo following the same schedule. Post-operative analgesic requirements were assessed using a patient-controlled analgesia system. Pain was assessed at rest using a visual analog scale in the post anesthetic care unit(PACU), 6 and 24 hours after surgery.

Conditions

• Efficacy of Dextromethorphan
• Morphine Consumption
• Pain

Interventions

Type	Name	Description
DRUG	pre-operatively followed by 30 mg three times per day after surgery

Timeline

• Start date: 2002-12-01
• Completion: 2003-12-01
• First posted: 2005-09-20
• Last updated: 2005-09-20

Locations

1 site across 1 country: Thailand