Trials / Completed
CompletedNCT00199082
Newly Diagnosed Mature B-ALL, Burkitt's Lymphoma and Other High-grade Lymphoma in Adults
Multicenter Study to Optimise Therapy of B-ALL, Burkitt's NHL and High-Grade Non-Hodgkin's Lymphoma in Adults (Amend 7)
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 650 (estimated)
- Sponsor
- Nicola Goekbuget · Academic / Other
- Sex
- All
- Age
- 15 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
The study evaluates the efficacy and tolerability of alternating short cycles of high-dose and conventional chemotherapy in combination with rituximab in CD20 positive patients, followed by local radiation therapy in the case of initial mediastinal or central nervous system (CNS) involvement or a residual tumor after chemotherapy. A dose-reduced regimen is offered for patients estimated to be over 55 years, biologically.
Conditions
- Burkitt's Lymphoma
- Burkitt's Leukemia
- Mediastinal Neoplasms
- Lymphoblastic Lymphoma
- Large Cell Anaplastic Lymphoma
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Adriamycin | |
| DRUG | Cyclophosphamide | |
| DRUG | Cytarabine | |
| DRUG | Dexamethasone/Prednisolone | |
| DRUG | VP16 | |
| DRUG | Ifosfamide | |
| DRUG | Methotrexate | |
| DRUG | G-CSF | |
| DRUG | Rituximab | |
| DRUG | Vincristine/Vindesine | |
| PROCEDURE | Irradiation (in specific conditions) |
Timeline
- Start date
- 2002-07-01
- Primary completion
- 2010-06-01
- Completion
- 2010-06-01
- First posted
- 2005-09-20
- Last updated
- 2022-08-19
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT00199082. Inclusion in this directory is not an endorsement.