NCT00196209

Cardioversion vs. Catheter Ablation for Persistent Atrial Fibrillation

Randomized Study Comparing Cardioversion vs. Catheter Ablation in Patients With Persistent Atrial Fibrillation

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 130 (estimated)
• Sponsor: Deutsches Herzzentrum Muenchen · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The aim of this randomized study is to evaluate the efficacy of two different approaches for conversion of persistent atrial fibrillation, the non-invasive one (external electrical cardioversion) and the invasive one (catheter ablation).

Detailed description

This randomized study compares two treatment strategies in patients with persistent atrial fibrillation: Cardioversion vs. catheter ablation. Cardioversion is a low risk standard treatment option for patients with persistent atrial fibrillation. However, mid- and long term efficacy (regarding the maintenance of sinus rhythm) is low. Catheter ablation is an invasive treatment which has been reported to result in up to 60-70% of patients in stable sinus rhythm. However, it is a potentially dangerous invasive procedure with potentially fatal complications. Comparison: External cardioversion vs. catheter ablation

Conditions

• Atrial Fibrillation

Interventions

Type	Name	Description
PROCEDURE	catheter ablation	catheter ablation to treat persistent atrial fibrillation
PROCEDURE	external electric cardioversion	external cardioversion and drug prophylaxis to treat persistent atrial fibrillation

Timeline

• Start date: 2005-08-01
• Primary completion: 2009-06-01
• Completion: 2009-12-01
• First posted: 2005-09-20
• Last updated: 2008-03-19

Locations

1 site across 1 country: Germany