NCT00186771

Magnetic Stimulation as a Treatment for Auditory Hallucinations in Schizophrenia

Transcranial Magnetic Stimulation Used to Treat Auditory Hallucinations in Schizophrenia

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: St. Joseph's Healthcare Hamilton · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Schizophrenia is a chronic, severe, and disabling brain disease. Auditory hallucinations are the most frequent symptoms with an incident of 50% to 70% in patients. Transcranial Magnetic Stimulation (TMS) can significantly reduce symptoms of schizophrenia. TMS is capable of inducing changes in the electrical activities of the brain in humans. The purpose of this trial is to study the use of TMS to decrease auditory hallucinations in schizophrenia.

Detailed description

We hypothesize that: True treatment with rTMS will have significant decrease in auditory hallucinations versus sham treatment over the temporoparietal cortex. FMRI will highlight areas of activation with auditory hallucinations distinct from the area identified by Hoffman's scalp based method. Cortical inhibition as measured by paired pulse TMS will be increased after true TMS but not sham TMS.

Conditions

• Schizophrenia

Interventions

Type	Name	Description
DEVICE	Paired Pulse	True treatment with rTMS over the temporoparietal cortex.
DEVICE	Paired Pulse	Sham treatment with rTMS over the temporoparietal cortex.

Timeline

• Start date: 2004-11-01
• Primary completion: 2012-01-01
• Completion: 2015-01-01
• First posted: 2005-09-16
• Last updated: 2011-07-28

Locations

2 sites across 1 country: Canada