NCT00186082

Antibiotics for Postpartum Third and Fourth Degree Perineal Tear Repairs

A Randomized Controlled Trial of the Effect of Prophylactic Antibiotics on the Infection Rate in Postpartum Third and Fourth Degree Perineal Tear Repairs

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 147 (actual)
• Sponsor: Stanford University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is undertaken to find out whether prophylactic antibiotics can decrease the infection rate in third and fourth degree perineal tear repairs done in the immediate postpartum period.

Detailed description

After obtaining consent patients who sustained third or fourth degree perineal laceration after vaginal delivery were randomly assigned to a single dose of antibiotic (cefotetan or cefoxitin, 1 g intravenously or clindamycin, 900 mg intravenously, if allergic to penicillin), or placebo (100ml normal saline) intravenously.

Conditions

• Pregnancy Complications, Infectious

Interventions

Type	Name	Description
DRUG	Cefotetan or Cefoxitin vs placebo	Cefotetan or Cefoxitin, 1 g intravenously, or Clindamycin, 900 mg intravenously. Normal Saline, 100 ml intravenously for placebo arm.

Timeline

• Start date: 2003-09-01
• Primary completion: 2006-06-01
• Completion: 2008-06-01
• First posted: 2005-09-16
• Last updated: 2011-06-15

Locations

2 sites across 1 country: United States