Trials / Completed

CompletedNCT00179946

HLA Matching - Unrelated Umbilical Cord Blood Transplantation

Impact of HLA Matching on Outcome in Pediatric Patients Undergoing Unrelated Umbilical Cord Blood Transplantation.

Status: Completed
Phase: —
Study type: Observational
Enrollment: 30 (estimated)

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago · Academic / Other
Sex: All
Age: —
Healthy volunteers: Not accepted

Summary

Detailed description

The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation. The study will answer the following questions: 1. Is HLA matching beneficial to unrelated UCB transplantation? 2. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 is/are important to math, or alternatively to mismatch, to improve graft survival? 3. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 mismatches is/are "permissive mismatches" or well tolerated mismatches? 4. What level of typing resolution (low, intermediate, or hgh) is required to perform patient/donor H:A matching? By studying the cells and blood of donors and recipients, we may learn more about improving the tissue matching between unrelated donors and their recipients. Also, we hope to learn if an additional level of matching testing improves the results of the transplant treatment. Increasing knowledge about tissue matching could result in the improved long-term survival of cord blood transplant recipients.

Conditions

Hematologic Diseases

Interventions

Type	Name	Description
PROCEDURE	HLA typing

Timeline

Start date: 2003-06-01
Primary completion: 2006-04-01
Completion: 2006-04-01
First posted: 2005-09-16
Last updated: 2025-01-30

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT00179946. Inclusion in this directory is not an endorsement.