NCT00179010

AMP as a Better Delivery System of Adenosine

Use of AMP to Improve Tissue Delivery of Adenosine

• Status: Terminated
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Vanderbilt University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart attacks. The problem in using adenosine is that it is taken up by cells and, therefore, very little of the adenosine we give by vein or in the artery actually reaches the tissue. We propose to use AMP as a way to improve delivery of adenosine. AMP is inactive by itself, but is converted to adenosine in tissue. We hope that by giving AMP we will increase levels of adenosine in tissue. To see if this is true, we will give either adenosine or AMP into the forearm artery while we measure how much adenosine reaches the forearm tissue.

Conditions

• Ischemia

Interventions

Type	Name	Description
DRUG	Adenosine	Adenosine intrarterial (intrabrachial) infusion at 3 diferent doses for 15 minutes each
DRUG	Adenosine Mono Phosphate (AMP)	Intraterial infusion of AMP at 3 different doses for 15 minutes each (at equimolar doses as adenosine)

Timeline

• Start date: 2003-10-01
• Primary completion: 2017-01-01
• Completion: 2017-01-01
• First posted: 2005-09-15
• Last updated: 2019-05-07
• Results posted: 2019-05-07

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study