NCT00177099

Effects of Ligands on Human Hair Follicles Grafted Onto SCID Mice

Neurotrophic Effects of Immunophilin Ligands on Human Hair Follicles Grafted Onto Service Combined Immunodeficient (SCID) Mice

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 35 (planned)
• Sponsor: Hordinsky, Maria K., MD · Individual
• Sex: Male
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine if immunophilin ligands may have the potential to reverse hair loss.

Detailed description

Preliminary experiments in C57BL/6J mice showed that immunophilin ligand FK506 and its non-immunosuppressive analogs, GP11046 and GP11511 were capable of promoting telogen to anagen transition. Since GP11046 and GP11511 possess the neurotrophic properties of FK506 without its immunosuppressant capability, the neural action of these immunophilin ligands may play an important role in the hair cycle. This finding has significant clinical implications in that immunophilin ligands may have the potential to reverse alopecia. To further investigate this possibility we propose to explore the response of transplanted miniaturized scalp hair follicles to topically applied immunophilin ligands.

Conditions

• Alopecia

Interventions

Type	Name	Description
DRUG	FK506, GP11046, GP11511

Timeline

• Start date: 2003-07-01
• Completion: 2004-09-01
• First posted: 2005-09-15
• Last updated: 2006-11-13

Locations

1 site across 1 country: United States