NCT00176618

The Effects of Curcuminoids on Aberrant Crypt Foci in the Human Colon

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Medicine and Dentistry of New Jersey · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the effectiveness of curcumin in reducing the number of aberrant crypt foci (ACF) in the colon.

Detailed description

Laboratory studies have indicated that this agent, which is derived from plants and found in foods we eat, has anti-inflammatory properties and prevents colon cancer in animal studies. ACFs are small abnormalities in the lining of the colon that with time may grow into colorectal adenomas (also called polyps, growths or small masses of tissue on the lining of the colon or rectum which have the potential to become cancerous) which can then grow into adenocarcinomas (cancer) in the colon or rectum.

Conditions

• Aberrant Crypt Foci

Interventions

Type	Name	Description
DRUG	sulindac	Sulindac 150 mg po BID
DRUG	curcumin	Curcumin 250 mg po BID

Timeline

• Start date: 2004-04-01
• Primary completion: 2007-06-01
• Completion: 2007-06-01
• First posted: 2005-09-15
• Last updated: 2009-12-11

Locations

1 site across 1 country: United States