NCT00175968

Influence of Bedrest and Hypocaloric Nutrition on Endothelium-Dependent Vasoreactivity

Influence of Bed-Rest and Hypocaloric Nutrition on Endothelium-Dependent Vasoreactivity

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 10 (planned)
• Sponsor: Heidelberg University · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Aim of the study is to assess the impact of the factors ´bed rest´ and ´hypocaloric nutrition´ on endothelium-dependent vasoreactivity in healthy volunteers.

Detailed description

In a randomized, four-phase cross-over study the effect of simulated microgravity (13 days of bed rest), energetic restriction (-25%, fat reduced), and their combination on endothelium-dependent and -independent vasodilation will be compared with ambulatory control conditions. Using venous occlusion plethysmography cumulative intraarterial dose-response curves to endothelium-dependent (acetylcholine) and -independent (sodium nitroprusside) vasodilators will be constructed in 10 healthy male volunteers before and on day 13 of each of the four intervention periods.

Conditions

• Healthy

Interventions

Type	Name	Description
PROCEDURE	bed rest, hypocaloric nutrition

Timeline

• Start date: 2001-03-01
• Completion: 2003-04-01
• First posted: 2005-09-15
• Last updated: 2005-09-15

Locations

1 site across 1 country: Germany