NCT00175227

Prevention of Contrast-Induced Nephropathy

Prevention of Contrast-Induced Nephropathy: a Randomized Controlled Trial of Saline + Furosemide + Mannitol in High Risk Patients Undergoing Cardiac Angiography

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: University of Alberta · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram. The investigators hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls.

Detailed description

Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram. We hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls. We define an episode of contrast nephropathy using the conventional often published definition of a 25% relative increase in serum creatinine OR a 44 umol absolute increase in serum creatinine within 48 hours of contrast exposure.

Conditions

• Contrast-induced Nephropathy
• Acute Renal Failure
• Chronic Renal Failure

Interventions

Type	Name	Description
DRUG	intravenous saline hydration + mannitol + furosemide	500 mls half-normal saline + 25g mannitol + 100 mg furosemide
DRUG	intravenous saline hydration	500 mls half-normal saline

Timeline

• Start date: 1996-05-01
• Primary completion: 2000-10-01
• First posted: 2005-09-15
• Last updated: 2011-05-10

Locations

1 site across 1 country: Canada