NCT00170196

Efficacy Studies of Corticosteroid Therapy in Community-Acquired Pneumonia

The CAPISCE-Trial: Community-Acquired Pneumonia; an Intervention Study With Corticosteroids

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 216 (actual)
• Sponsor: Medical Center Alkmaar · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the efficacy of addition of corticosteroid therapy to antibiotics in patient admitted with Community-acquired pneumonia. The hypothesis is: Prednisolone in combination with antibiotic treatments is effective in improving clinical outcome in patients hospitalized with CAP.

Detailed description

Community-acquired pneumonia (CAP) is a acute illness with a considerable morbidity and mortality, especially patients with severe CAP. In the past decennia, in spite of many investigations, little reduction is seen in morbidity an mortality. Corticosteroids have a immune-modulation effect, which is not completely elucidated. Most likely the immune modulation effect is due to down-regulation of pro-inflammatory cytokines. The use of corticosteroids next to antibiotics in CAP could lead to shorter time to clinical stability, length of stay and costs. Comparison: Hospitalized patients with CAP treated with antibiotics and prednisolone versus hospitalized patients with cap treated with antibiotics and placebo

Conditions

• Pneumonia

Interventions

Type	Name	Description
DRUG	prednisone

Timeline

• Start date: 2005-08-01
• Primary completion: 2008-08-01
• Completion: 2008-09-01
• First posted: 2005-09-15
• Last updated: 2008-09-29

Locations

1 site across 1 country: Netherlands