NCT00169806

Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis

Randall's Plaques: Pathogenesis and Relationship to Nephrolithiasis

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: Indiana Kidney Stone Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Kidney stones are very common. They affect 3-5% of the population in the United States. Many people are hospitalized for the treatment of kidney stones and some may die. Better understanding of what causes kidney stones is useful in both the treatment and prevention of kidney stones. However, exactly what causes kidney stones is unknown. The most common type of kidney stones contains calcium, which sometimes is attached to a part of the kidney important in producing the final urine, called the papilla. The investigators have noticed that persons who form kidney stones seem to have more papilla with stones attached. They propose to study these areas of the papilla, called Randall's plaques (named after their discoverer), in patients undergoing surgery for kidney stones.

Detailed description

In order to attempt to explain the pathogenesis of renal calculi, the investigators videotape and document the location and characteristics of each stone, papillae and calyces. One or more small papillary biopsies are taken for analysis to help determine the point of origin of the kidney stone and histological studies are undertaken to determine tissue differences amongst different types of stone formers. Approximately one month after surgery, metabolic studies are undertaken to further review potential causes of stone formation.

Conditions

• Nephrocalcinosis
• Renal Calculi
• Hypercalciuria
• Hyperparathyroidism
• Cystinuria

Interventions

Type	Name	Description
OTHER	videotape for mapping of renal anatomy and papillary biopsy	Subjects who enroll in this study will have their renal anatomy videotaped for mapping purposes. Stone location and characteristics will be documented as will papilla and calyces. One or more papillary biopsies will be taken for analysis.

Timeline

• Start date: 1998-11-01
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2005-09-15
• Last updated: 2025-01-23

Locations

1 site across 1 country: United States