Trials / Terminated
TerminatedNCT00169039
Clozapine Versus Chlorpromazine for Treatment-Unresponsive Schizophrenia
Clozapine Response and Biogenic Amines in Schizophrenia
- Status
- Terminated
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 66 (planned)
- Sponsor
- Harvard Medical School (HMS and HSDM) · Academic / Other
- Sex
- All
- Age
- 19 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
This study will examine the physical response to clozapine or chlorpromazine in people with schizophrenia that has not improved with treatment.
Detailed description
This is a longitudinal double-blind 12-week study of the clinical and biochemical response to clozapine or chlorpromazine in a group of treatment-refractory schizophrenic patients. The study has 4 phases: (1) A recruitment period; (2) a period of discontinuation of psychotropic medication; (3) a drug-washout period; and (4) a 12-week double-blind trial of clozapine or chlorpromazine.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Clozapine | |
| DRUG | Chlorpromazine |
Timeline
- Start date
- 1994-12-01
- Completion
- 2002-02-01
- First posted
- 2005-09-15
- Last updated
- 2015-04-07
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00169039. Inclusion in this directory is not an endorsement.