NCT00168649

Vitamin A and Response to Endotoxin

The Effect of Vitamin A on the Response to Endotoxin

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (planned)
• Sponsor: Bandim Health Project · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Vitamin A given as treatment and pre-treatment has reduced the severity of symptoms after infusion with endotoxin in several animal models. We intend to examine the effect of vitamin A as pre-treatment on the response to endotoxin in humans. We furthermore wish to examine the long-term effects of vitamin A on the response to endotoxin. We hypothesise that vitamin A decreases endotoxin levels and TNF-alfa responses.

Detailed description

Vitamin A given as treatment and pre-treatment has reduced the severity of symptoms after infusion with endotoxin in several animal models. We intend to examine the effect of vitamin A as pre-treatment on the response to endotoxin in humans. As studies in children in low-income countries have indicated that vitamin A has long-term effects on the immune system, we furthermore wish to examine the long-term effects of vitamin A on the response to endotoxin. This will be done in an established model using infusion with endotoxin to male human volunteers. We hypothesise that vitamin A decreases endotoxin levels and TNF-alfa responses. Furthermore, we hypothesise that it reduces oxidative stress and injury.

Conditions

• TNF-alfa
• Endotoxin Levels

Interventions

Type	Name	Description
DRUG	Vitamin A

Timeline

• Start date: 2005-06-01
• Completion: 2014-06-01
• First posted: 2005-09-15
• Last updated: 2013-11-15

Locations

1 site across 1 country: Denmark