NCT00168246

Determining the Prevalence of HIV-Related Neurological Disorders in the Asia Pacific

A Cross-Sectional Study of HIV-Related Neurological Disorders in Ten Countries of the Asia Pacific Region

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 600 (planned)
• Sponsor: National Institute of Mental Health (NIMH) · NIH
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This study will determine the prevalence of HIV-related neurological disorders in the countries of the Asia-Pacific Region.

Detailed description

This a cross-sectional study to determine the prevalence of HIV-related Neurological Disorders in the countries of the Asia-Pacific Region. Researchers will visit each country site for a period of 2-3 weeks and work with local investigators. Outpatients will be evaluated once-only for the presence of HIV-related symptomatic peripheral neuropathy and HIV-related Neurocognitive Impairment. Inpatients at the sites will be evaluated once-only for the presence of HIV dementia, cerebral toxoplasmosis, cerebral tuberculosis, cryptococcal meningitis, lymphoma, PML and CMV encephalitis. The Primary outcomes are: 1. To determine the prevalence of HIV-related neurocognitive impairment and ADC at the APNAC-10 sites 2. To determine the prevalence of symptomatic peripheral sensory neuropathy at the APNAC-10 sites 3. To determine the prevalence of central nervous system opportunistic infections and tumours at the APNAC-10 sites The secondary outcomes are: To determine the degree of cognitive impairment in patients presenting with HIV-related cognitive impairment at the APNAC-10 sites * To determine the CD4 cell counts, HIV viral loads HIV viral loads and prior AIDS defining illnesses (ADIs) of patients presenting with HIV-related neurocognitive impairment and ADC at the APNAC-10 sites * To compare the prevalence of HIV-related neurocognitive impairment and ADC at the APNAC-10 sites to the published pre-HAART prevalence of these conditions in developed countries * To compare the prevalence of HIV-related neurocognitive impairment and ADC between the APNAC-10 sites * To describe the severity of symptoms of patients presenting with symptomatic peripheral sensory neuropathy at the APNAC-10 sites * To determine the CD4 cell counts, HIV viral loads HIV viral loads and prior ADIs of patients presenting with symptomatic peripheral sensory neuropathy at the APNAC-10 sites * To determine what proportion of symptomatic peripheral sensory neuropathy may be ascribed to HIV alone, to the use of nucleoside analogues * To compare the prevalence of symptomatic peripheral sensory neuropathy at the APNAC-10 sites to the published pre-HAART prevalence of these conditions in developed countries * To compare the prevalence of symptomatic peripheral sensory neuropathy between the APNAC-10 sites * To determine the prevalence of asymptomatic peripheral neuropathy * To describe the presenting symptoms and signs of patients presenting with CNS OIs and tumours at the APNAC-10 sites * To describe the neuroradiological findings of patients presenting with CNS OIs and tumours at the APNAC-10 sites * To determine the serological, culture and other diagnostic test results of patients presenting with CNS OIs and tumours at the APNAC-10 sites * To determine the CD4 cell counts, HIV viral loads and prior ADIs of patients presenting with CNS OIs and tumours at the APNAC-10 sites * To compare the prevalence of CNS OIs and tumours at the APNAC-10 sites to the published pre-HAART prevalence of these conditions in developed countries * To compare the prevalence of CNS OIs and tumours between the APNAC-10 sites

Conditions

• HIV Infections
• HIV Related Neurological Diseases

Timeline

• Start date: 2005-06-01
• First posted: 2005-09-15
• Last updated: 2007-02-27

Locations

1 site across 1 country: Australia