NCT00165438

Pulmonary Function in Patients With Hodgkin's Disease Receiving Bleomycin-Based Chemotherapy

A Prospective Study of Pulmonary Function in Patients With Hodgkin's Disease Receiving Bleomycin-Based Chemotherapy With or Without Mediastinal Irradiation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Dana-Farber Cancer Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to find out the impact Bleomycin-containing chemotherapy, given with or without chest radiation therapy, on patients' lung function over time.

Detailed description

* The tests and procedures in this study are part of regular cancer care but this study offers more structured timing of these standard tests. * Due to the potential lung toxicity associated with bleomycin-based chemotherapy, pulmonary function tests are routinely performed. Pulmonary function tests will be performed by a licensed, registered respiratory therapist and performed prior to the beginning of treatment, between the chemotherapy and radiation therapy (only for patients receiving both chemotherapy and radiation therapy), and at approximately 1 month, 6 months, 1 year and 2 years after the completion of all treatments. * A CAT scan will be performed prior to the beginning of treatment, and approximately 1 month, 6 months, 1 year and 2 years after the completion of all treatments. * A self-administered questionnaire will be performed on the days the patient is undergoing pulmonary function tests.

Conditions

• Hodgkin's Disease

Interventions

Type	Name	Description
PROCEDURE	Pulmonary Function Tests	Tests include; total lung capacity, vital capacity, functional residual capacity, forced vital capacity, forced expiratory volume in 1 second, carbon monoxide diffusing capacity, pulse oximetry before and after a 6 minute walk and Pulmonary Status and Dyspnea Questionnaire
PROCEDURE	CAT Scan	Obtained at different time points during the study depending upon standard of care chemotherapy treatment

Timeline

• Start date: 2001-10-01
• Primary completion: 2005-11-01
• Completion: 2010-01-01
• First posted: 2005-09-14
• Last updated: 2012-12-20

Locations

2 sites across 1 country: United States