NCT00164216

Efficacy and Effectiveness of Combined Therapy for Uncomplicated Malaria Treatment in Peru

Evaluation of the Efficacy and Effectiveness of Combined Therapy With Mefloquine and Artesunate for Uncomplicated Malaria Treatment in the Loreto Region (Amazon Basin), Peru

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 208 (actual)
• Sponsor: Centers for Disease Control and Prevention · Federal
• Sex: All
• Age: 1 Year
• Healthy volunteers: Not accepted

Summary

This is a study of the efficacy and effectiveness of combination therapy for malaria due to P. falciparum in the Loreto Department, Iquitos, Peru. The investigators will enroll subjects ≥ 1 year-old who have a diagnosis of uncomplicated malaria due to P. falciparum. Patients will receive a treatment regimen consisting of mefloquine (25 mg/kg per day for two days) and artesunate (12 mg/kg per day for three days). Patients will be divided into two groups: one will receive drugs under direct supervision and the other will be instructed on how to take the drugs by themselves. Clinical and parasitologic response will be monitored for a follow-up period of 28 days. The findings of this study will be used to guide the Ministry of Health in evaluating its national policy for P. falciparum malaria treatment.

Conditions

• Malaria Falciparum

Interventions

Type	Name	Description
DRUG	mefloquine plus artesunate

Timeline

• Start date: 2005-03-01
• Primary completion: 2008-03-01
• Completion: 2008-03-01
• First posted: 2005-09-14
• Last updated: 2012-09-11

Locations

1 site across 1 country: Peru