NCT00159523

Impact in Off-spring of Mothers After Perinatal Daily Intake of a Probiotic

The Impact of Perinatal Daily Supplement of a Probiotic (Lactobacillus Rhamnosus GG), Given to Mothers, on Immunological Development, Atopic Sensitisation and Allergic Disease in Their Off-spring

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 416 (actual)
• Sponsor: Norwegian University of Science and Technology · Academic / Other
• Sex: All
• Age: 30 Weeks – 36 Weeks
• Healthy volunteers: Accepted

Summary

A probiotic (Lactobacillus rhamnosus GG) supplement to pregnant women the last four weeks of pregnancy and three months after birth is expected to give a 40% reduction in risk of atopic sensitisation and allergic disease at two years of age, compared to placebo.

Detailed description

To investigate how probiotics given to pregnant women during the last 4 weeks of pregnancy and the first 4 months after birth influence the establishment and composition of the gut microflora in children from birth until two years of age. At the same time to investigate the relationship between gut flora composition and the development of the immune system. To investigate the relationship between supplement of probiotics to pregnant and breast-feeding women, the microbial composition of the gut flora in their children, the development of the childrens' immune system, and the prevalence of atopic sensitisation and atopic disease at two years of age.

Conditions

• Asthma
• Dermatitis, Atopic
• Rhinitis, Allergic, Perennial

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotic
BIOLOGICAL	placebo

Timeline

• Start date: 2003-12-01
• Primary completion: 2007-09-01
• Completion: 2007-09-01
• First posted: 2005-09-12
• Last updated: 2016-02-05

Locations

1 site across 1 country: Norway