NCT00159302

Biomarkers of iNOS Activity in COPD, Asthma, Healthy Control

A Pilot Study to Evaluate and Develop Biomarkers of iNOS Activity in Patients With COPD or Asthma and Healthy Volunteers

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This pilot study will measure the baseline levels and the intra- and inter-subject variability of exhaled (alveolar and bronchial) and nasal NO in smoking subjects with mild and moderate COPD on or off steroid treatment, smoking healthy volunteers and non-smoking mild asthmatics off steroids, using multiple exhalation flow rates. I

Detailed description

n addition, exploratory markers of iNOS activity (eg. 3-nitrotyrosine, nitrite, nitrate and 3-nitro-4-hydoxyphenylacetic acid) in blood, sputum, urine and exhaled breath condensate will be evaluated. We will also evaluate exhaled and nasal NO in a population of mild asthmatics in order to obtain baseline and variability data for future clinical studies involving asthmatic subjects.

Conditions

• Healthy Smokers
• Healthy Non-smokers
• Patients With Mild Asthma
• Patints With COPD (GOLD II)

Interventions

Type	Name	Description
PROCEDURE	Induced Sputum
PROCEDURE	Exhaled Nitric Oxide
PROCEDURE	Nasal Nitric Oxide
PROCEDURE	Blood Tests
PROCEDURE	24hr Urine Samples
PROCEDURE	Exhaled Breath Condensate
PROCEDURE	Spirometry

Timeline

• Start date: 2003-09-01
• Primary completion: 2006-09-01
• Completion: 2006-09-01
• First posted: 2005-09-12
• Last updated: 2019-07-10

Locations

1 site across 1 country: United Kingdom