NCT00157859

To Evaluate Current Efficacy of Antimalarials Used in Timika, Papua, Indonesia

To Evaluate the Efficacy of Chloroquine and SP for Acute Uncomplicated P. Falciparum and the Efficacy of Chloroquine for Acute Uncomplicated P. Vivax in the Timika Region of Papua, Indonesia.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (planned)
• Sponsor: Menzies School of Health Research · Academic / Other
• Sex: All
• Age: 12 Months
• Healthy volunteers: Not accepted

Summary

Multidrug resistant strains of P.falciparum and P.vivax are becoming increasingly prevalent in the Asia Pacific rim. To determine the efficacy of locally recommended antimalarial protocols in Papua, Indonesia, consecutive patients presenting to a rural clinic were enrolled into a prospective efficacy study. Patients with uncomplicated falciparum malaria were treated with chloroquine plus sulfadoxine-pyrimethamine and those with vivax malaria with chloroquine monotherapy. Patients failing therapy received unsupervised oral quinine +/- doxycycline for 7 days. Follow-up was continued for 42 days for falciparum malaria and 28 days for vivax malaria. The study hypothesis was that current recommended antimalarial protocols were no longer effective.

Conditions

• Falciparum Malaria
• Vivax Malaria

Interventions

Type	Name	Description
DRUG	Chloroquine and sulphadoxine-pyrimethamine

Timeline

• Start date: 2004-04-01
• Completion: 2004-09-01
• First posted: 2005-09-12
• Last updated: 2005-09-12

Locations

1 site across 1 country: Indonesia