NCT00154037

Investigation of Vascular Relaxing Effects of Candesartan and Pioglitazone.

Characterization of Vascular Effects of Candesartan and Pioglitazone.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (planned)
• Sponsor: Technische Universität Dresden · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The study is designed to test the hypothesis in healthy subjects that candesartan and pioglitazone provide additional vascular relaxing or modulating effects in addition to their blood-pressure and blood glucose level reducing ability, respectively.

Detailed description

The aim of the study is to investigate the effect of oral candesartan and/ or rosiglitazone therapy on the vascular responsiveness of different vasoactive compounds (angiotensin II, insulin, histamine and glyceroltrinitrate) in healthy subjects. Pioglitazone will be given orally (4 weeks 30mg/d, titrated to 45 mg/d for another 4 weeks). Candesartan will be given orally (4 weeks 8mg/d, titrated to 16 mg/d for another 4 weeks) as treatment. Every subject will receive intravenous stimulation with phenylephrine, angiotensin II, histamine, insulin and glyceroltrinitrate before and after an 8 weeks treatment interval with study medication or placebo. In addition, pulse wave velocity will me measured non-invasively before and after treatment.

Conditions

• Healthy Subjects

Interventions

Type	Name	Description
DRUG	Pioglitazone (drug) and/or candesartan (drug)

Timeline

• Start date: 2005-10-01
• Completion: 2006-09-01
• First posted: 2005-09-12
• Last updated: 2006-09-13

Locations

1 site across 1 country: Germany