NCT00153725

Intravenous Pantoloc In Aspirin-Induced Ulcer Bleeding

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 156 (planned)
• Sponsor: Chinese University of Hong Kong · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to investigate whether intravenous infusion of pantoprazole (Pantoloc) is effective in preventing recurrent bleeding in patients who present with acute ulcer bleeding and continue to use aspirin

Detailed description

Aspirin is an effective treatment for acute stroke and heart attack. However, aspirin also induces ulcer and provokes acute ulcer bleeding. Thus, aspirin is often withheld in acute ulcer bleeding but this precipitate recurrent stroke or heart attack. We previously showed that intravenous infusion of a potent acid suppressant substantially reduced the incidence of recurrent ulcer bleeding in patients who withheld aspirin. The aim of this study is to investigate whether intravenous infusion of an acid suppressant (Pantoprazole) is effective in preventing recurrent ulcer bleeding with continuous use of aspirin.

Conditions

• Cardiovascular Disease
• Cerebrovascular Disorders

Interventions

Type	Name	Description
DRUG	Aspirin and Pantoloc

Timeline

• Start date: 2003-02-01
• Completion: 2006-09-01
• First posted: 2005-09-12
• Last updated: 2006-10-27

Locations

3 sites across 1 country: China