NCT00151905

The Use of an Inhaled Salt Solution to Treat Viral Lung Infections in Infants.

Nebulized Hypertonic Saline in the Treatment of Bronchiolitis in Infants

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: —
• Sponsor: Sheikh Khalifa Medical City · Academic / Other
• Sex: All
• Age: 18 Months
• Healthy volunteers: Not accepted

Summary

Bronchiolitis is a common viral lung infection in infants. Standard treatment often includes the use of inhaled medications which are usually first mixed with a standard salt solution. Inhalation of a more concentrated salt solution (hypertonic saline) has been successfully used to treat other types of lung disease in children and adults. The purpose of this study is to see if using inhaled hypertonic saline helps infants with bronchiolitis get better more quickly.

Detailed description

Bronchiolitis is a common illness in infants and is associated with a significant morbidity. Standard therapy is controversial and largely ineffective; care is mostly supportive although nebulized medications continue to be commonly used. These medications are typically mixed with normal saline to produce a sufficient volume for efficient nebulization. Inhaled hypertonic saline has been used to aid airway clearance in children with cystic fibrosis. It has also been used, in low dose, in two small studies in children with bronchiolitis. The current study is a randomized, double-blind, placebo-controlled, multi-center trial comparing frequent dosing with 3% hypertonic saline compared to normal saline in the treatment of infants hospitalized with bronchiolitis.

Conditions

• Bronchiolitis

Interventions

Type	Name	Description
DRUG	3 % hypertonic saline

Timeline

• Start date: 2003-11-01
• Completion: 2006-09-01
• First posted: 2005-09-09
• Last updated: 2007-05-07

Locations

3 sites across 2 countries: Canada, United Arab Emirates