NCT00150514

Effects of Sublingual Immunotherapy on Grasspollen Allergy

A Placebo Controlled, Double-Blind, Randomised Study to Assess Efficacy of Sublingual Immunotherapy in Patients With Grass Pollen Allergy Through Assessment of Its Immunological Effects on the Mucosal Tissue of the Nose.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 38 (planned)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The objective of the study is to document the objective immunological effects of SLIT on the nasal mucosa. Better understanding of these immunological pathways, in which this widely practised clinical therapy is likely to work, can only benefit the overall outcome of this, more patient friendly, therapy and it will demonstrate the effects of SLIT on the allergic reaction, with objective parameters, in the nasal tissues showing it to be a true etiological treatment of allergy.

Detailed description

Double blind placebo controlled evaluation of the immunological effects (decrease of IgE specific cells and the decrease of Th2 mediator release, respectively increase of Th1 mediator release) of SLIT on the nasal mucosal tissue of adult humans with severe rhinocunjunctivitis due to grass pollen allergy.

Conditions

• Hayfever

Interventions

Type	Name	Description
DRUG	Oralgen
PROCEDURE	Nasal biopsy
PROCEDURE	Nasal washing
PROCEDURE	Peak nasal inspiratory flow

Timeline

• Start date: 2002-01-01
• Completion: 2006-12-01
• First posted: 2005-09-08
• Last updated: 2005-09-08

Locations

1 site across 1 country: Netherlands