Trials / Completed
CompletedNCT00149253
Pre-Emptive Analgesia Efficacy of Etoricoxib for Postoperative Pain
A Randomized, Double-Blind, Controlled Trial of Etoricoxib as a Pre-Emptive Analgesic for Abdominal Hysterectomy
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 50 (planned)
- Sponsor
- Khon Kaen University · Academic / Other
- Sex
- Female
- Age
- 15 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
Taken together, studies of the value of pre-emptive analgesia are inconclusive. This randomized, double-blind, dose-ranging, placebo-controlled study was therefore designed to test that a reduction in post-operative morphine consumption can be achieved by a single-dose of etoricoxib before induction of anesthesia.
Detailed description
Patients undergoing transabdominal hysterectomy were randomized to a group taking a single dose (orally) of etoricoxib 120 mg (n = 18), etoricoxib 180 mg (n = 17) or placebo (n = 15) 2 hours before surgery under the same standardized general anesthesia. At the post-anesthetic care unit, intravenous morphine titration was given before starting self-controlled analgesia (PCA) device. Morphine consumption, pain relief score, sedative score, global evaluation score, and side-effects were recorded at 1, 2, 4, 8 and 24 h post-operatively. The primary end points were morphine consumption within 24-hr post-operatively and total pain relief over 8 h (TOPAR8). Patient global satisfaction was also assessed.
Conditions
- a Single-Dose of Etoricoxib
- Post-Operative Morphine Consumption
- Total Pain Relief Over 8 Hr(TOPAR8)
- Post Transabdominal Hysterectomy
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | a single-dose of Etoricoxib before induction of anesthesia |
Timeline
- Start date
- 2004-12-01
- Completion
- 2005-05-01
- First posted
- 2005-09-08
- Last updated
- 2005-09-08
Locations
1 site across 1 country: Thailand
Source: ClinicalTrials.gov record NCT00149253. Inclusion in this directory is not an endorsement.