NCT00142389

Mother's Gift Project

Comparison of Maternal and Infant Immunization Strategies to Prevent Pneumococcal Disease

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 680 (planned)
• Sponsor: Johns Hopkins Bloomberg School of Public Health · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This prospective randomized evaluation of pneumococcal vaccine immunization of pregnant mothers, followed by pneumococcal conjugate immunization of their children is designed to assess the effects of these strategies on the immunogenicity and safety of both vaccines. We hypothesize that maternal followed by infant immunization will be safe and will provide higher levels of antibody from birth through 12 months of age.

Detailed description

This is a randomized vaccine evaluation in 4 groups of mothers and their infants, to assess the effect of maternal immunization on the infants' response to pneumococcal vaccine.

Conditions

• Pneumococcal Infections

Interventions

Type	Name	Description
BIOLOGICAL	pneumococcal polysaccharide and protein conjugate vaccines

Timeline

• Start date: 2004-08-01
• Completion: 2006-12-01
• First posted: 2005-09-02
• Last updated: 2011-06-23

Locations

1 site across 1 country: Bangladesh