NCT00141596

Extracellular Fluid in Resistant Hypertension

A Study to Investigate the Contribution of Extracellular Fluid Volume Expansion to Drug Resistant Hypertension

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: St George's, University of London · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The optimal treatment of drug resistant (defined as BP\> 140/85 despite three anti-hypertensive drugs including a diuretic) is not well defined. This study aims to test the hypothesis that resistant hypertension is caused by excessive expansion of extracellular fluid volume. A secondary objective is to study which of three different antihypertensive drugs would be most useful in drug resistant hypertension.

Detailed description

Following recruitment subjects will have ECV measured by 51Cr-EDTA determination of GFR, with Brochner-Mortensen correction applied. Subjects then receive the following drugs, in a randomised fashion, for a period of four weeks each, with BP \& ECV measurement at end of each period: doxazosin GITS (Cardura XL) 4 mg b.d.; frusemide 40 mg b.d.; amiloride 5 mg b.d.; placebo.

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	Cardura XL 4 mg bd
DRUG	Amiloride 5 mg bd
DRUG	Furosemide 40 mg bd

Timeline

• Start date: 2003-07-01
• Completion: 2006-10-01
• First posted: 2005-09-01
• Last updated: 2015-06-09

Locations

1 site across 1 country: United Kingdom