NCT00137254

Insulin on Post Burn Hypermetabolism

Effects of Insulin on Post Burn Hypermetabolism

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: United States Army Institute of Surgical Research · Federal
• Sex: All
• Age: 18 Years – 72 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the effects of insulin on helping burn patients recover faster from their burns.

Detailed description

Severe injuries produce profound hypermetabolic stress responses which cause severe loss of lean body mass and muscle wasting, immunologic compromise, slowed wound healing, and related bone loss, all which contribute to increased morbidity, mortality, and prolonged recovery from injury. The results of hypermetabolism persist for weeks to months depending on the severity of the insult. Massive burns can cause severe catabolism and are an excellent model to study the general effects of injury on protein metabolism. Severe burns are characterized by dramatic increases in energy utilization and alterations in the metabolism of carbohydrates, fat, and protein. Insulin treatment improves net protein synthesis in the severely burned, principally through improved muscle protein synthesis. Although controversy exist as to whether insulin is effective as an anabolic hormone through increasing protein synthesis or decreasing protein breakdown, we believe that consideration of the methods and experimental protocols used in the various studies bear consideration when evaluating this topic.

Conditions

• Burns

Interventions

Type	Name	Description
DRUG	Insulin	IV insulin
DRUG	Stable Isotopes	IV administration of stable isotopes
DRUG	Indocyanine Green	IV administration of ICG

Timeline

• Start date: 2005-12-01
• Primary completion: 2007-02-01
• Completion: 2008-08-01
• First posted: 2005-08-29
• Last updated: 2012-04-12

Locations

1 site across 1 country: United States