Trials / Completed
CompletedNCT00137202
Post Burn Pruritus Study in Patients Undergoing Wound Healing
A Pilot Study to Determine the Pruritic Benefits of Ondansetron Versus Diphenhydramine in Burn Patients Undergoing Wound Healing
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 36 (actual)
- Sponsor
- United States Army Institute of Surgical Research · Federal
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to see if a drug called ondansetron (Zofran) controls itching from healing burn wounds as well or better than the usual drug used, diphenhydramine (Benadryl).
Detailed description
A clear mechanism or cause for pruritus in patients recovering from burn has not been delineated. While the exact mechanisms/pathways for itching are currently unclear, histamine antagonism appears to be the most popular treatment. Whether histamine antagonism works predominantly via peripheral inhibition or central sedation is uncertain. By treating another intermediary in the pruritus cascade, it may be possible that an alternate treatment could be used while eliminating some of the unwanted side effects of antihistamine at the same time.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Ondansetron (Zofran) | |
| DRUG | Diphenhydramine (Benadryl) |
Timeline
- Start date
- 2005-06-01
- Primary completion
- 2006-05-01
- Completion
- 2006-05-01
- First posted
- 2005-08-29
- Last updated
- 2008-07-28
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00137202. Inclusion in this directory is not an endorsement.