NCT00133302

Study of Standard CHOP Versus Biweekly CHOP in Aggressive Non-Hodgkin's Lymphoma (JCOG9809)

Randomized Phase III Study of Standard CHOP (S-CHOP) Versus Biweekly CHOP (Bi-CHOP) in Aggressive Non-Hodgkin's Lymphoma (JCOG9809)

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 450 (planned)
• Sponsor: Japan Clinical Oncology Group · Academic / Other
• Sex: All
• Age: 15 Years – 69 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this trial is to investigate the clinical benefit of the dose intensified regimen, Bi-CHOP in comparison to standard CHOP for advanced intermediate or high grade non-Hodgkin's lymphoma (NHL).

Detailed description

The purpose of JCOG9809 was to determine whether treatment results of aggressive NHL could be improved by shortening intervals of CHOP chemotherapy with the prophylactic use of G-CSF. The primary endpoint was Progression Free Survival (PFS), and the planned accrual was 450. Until December, 2002, 323 patients with advanced aggressive NHL were randomized to standard CHOP arm (CHOP x 8, every three weeks) and biweekly CHOP arm (CHOP x 8, every two weeks).

Conditions

• Non-Hodgkin's Lymphoma

Interventions

Type	Name	Description
DRUG	Standard CHOP
DRUG	Bi-CHOP (dose intensified CHOP)

Timeline

• Start date: 1999-02-01
• Completion: 2005-02-01
• First posted: 2005-08-23
• Last updated: 2007-01-18

Locations

1 site across 1 country: Japan