NCT00123643

Vascular Effects of Rosiglitazone Versus Glyburide in Type 2 Diabetic Patients

Comparison of Rosiglitazone Versus Glyburide on Vascular Structure and Function in Type 2 Diabetic Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: St. Paul Heart Clinic · Academic / Other
• Sex: All
• Age: 25 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the vascular effects of two commonly used diabetes medications, rosiglitazone and glyburide in type 2 diabetic patients.

Detailed description

Rosiglitazone and glyburide are two commonly used diabetic medications that have both been shown to be effective in controlling blood glucose levels. Since they work in different ways, they may have different effects on the health of the blood vessels. This study will assess which medication is better at improving the health of the arteries separate from the blood glucose lowering effects. Artery health will be assessed non-invasively by ultrasound. Certain markers of atherosclerosis found in the blood will also be measured.

Conditions

• Type 2 Diabetes Mellitus

Interventions

Type	Name	Description
DRUG	rosiglitazone
DRUG	glyburide

Timeline

• Start date: 2003-05-01
• Primary completion: 2005-12-01
• Completion: 2005-12-01
• First posted: 2005-07-25
• Last updated: 2013-07-15
• Results posted: 2012-08-09

Locations

1 site across 1 country: United States