NCT00123604

Vascular Effects of Carvedilol Versus Metoprolol in Hypertensive Patients With Type 2 Diabetes

Effects of Carvedilol and Metoprolol on Endothelial Function in Hypertensive Patients With Type 2 Diabetes Mellitus

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: St. Paul Heart Clinic · Academic / Other
• Sex: All
• Age: 30 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the vascular effects of two commonly used blood pressure medications, carvedilol and metoprolol in hypertensive patients with type 2 diabetes.

Detailed description

Carvedilol and metoprolol are two commonly used blood pressure medications that have both been shown to be effective in controlling hypertension. Although in the same drug class, preliminary data have shown that these medications may have different vascular effects. This study will assess which medication is better at improving artery health independent of their blood pressure lowering effects. Artery health will be assessed non-invasively by ultrasound. Certain markers of atherosclerosis found in the blood will also be measured.

Conditions

• Hypertension
• Type 2 Diabetes Mellitus

Interventions

Type	Name	Description
DRUG	Carvedilol	25 mg twice daily for five months.
DRUG	Metoprolol	200 mg twice daily for five months.

Timeline

• Start date: 2004-06-01
• Primary completion: 2006-06-01
• Completion: 2006-06-01
• First posted: 2005-07-25
• Last updated: 2014-11-18
• Results posted: 2014-11-18

Locations

1 site across 1 country: United States