NCT00123266

Intra-arterial Microplasmin Administration in Patients With Acute Intracranial Vertebrobasilar Artery Occlusion

An Open-label, Clinical Trial of Intra-arterial Microplasmin Administration in Patients With Acute Intracranial Vertebrobasilar Artery Occlusion

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 2 (actual)
• Sponsor: ThromboGenics · Industry
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the trial is to evaluate the safety of microplasmin as well as its ability to open blocked arteries to the brain in patients with acute stroke when given into the artery at the site of the blockage.

Detailed description

Patients with angiographically documented acute intracranial vertebrobasilar artery occlusion presenting within 24 hours of neurological symptom onset will be enrolled into this open-label trial. During study drug administration, angiograms will be repeated at regular intervals to determine degree of clot lysis.

Conditions

• Stroke

Interventions

Type	Name	Description
DRUG	Microplasmin	2 mg/kg, IA over 75 mins

Timeline

• Start date: 2006-12-01
• Primary completion: 2007-07-01
• Completion: 2008-08-01
• First posted: 2005-07-22
• Last updated: 2014-04-07

Locations

7 sites across 2 countries: Germany, Netherlands