NCT00119990

Changes in Cardiovascular Hemodynamics During Peritoneal Dialysis

Changes in Cardiovascular Hemodynamics During Peritoneal Dialysis; the Effect of Different Dialysates

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

During peritoneal dialysis, water is removed from the body. This sometimes occurs at rates of up to 500 ml/h. During shifts with dialysate with high glucose content, an increase in blood pressure has been described. The effect upon central hemodynamics is unknown. The researchers are investigating the effects of low and high glucose dialysate and icodextrin on cardiac output, stroke volume, pulse rate and blood pressure. The researchers have hypothesized that the effects seen are induced by vasopressin.

Conditions

• Peritoneal Dialysis

Interventions

Type	Name	Description
DRUG	Icodextrin (dialysate)	2 liter of extraneal are given with one fill for 4 hours.
DRUG	Physioneal (dialysate) 1.36% and 2.27%	2 liter of Physioneal of 1.36% or 3.86% are given with one fill for 4 hours one two different days.

Timeline

• Start date: 2006-01-01
• Primary completion: 2009-01-01
• Completion: 2010-01-01
• First posted: 2005-07-14
• Last updated: 2008-12-08

Locations

1 site across 1 country: Denmark