NCT00119795

Exercise and Weight Loss for Improving Mobility in Older Adults Who Are Obese

Cooperative Lifestyle Intervention Program (CLIP)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 288 (actual)
• Sponsor: Wake Forest University Health Sciences · Academic / Other
• Sex: All
• Age: 60 Years – 79 Years
• Healthy volunteers: Not accepted

Summary

To test the effects of exercise and weight loss on mobility disability of older overweight/obese men and women who have evidence of cardiovascular disease or the metabolic syndrome.

Detailed description

BACKGROUND: Older adults make up the fastest growing segment of our population. It is estimated that by the year 2030, elderly people will make up 22% of the United States population. A large portion of older adults suffers from one or more chronic conditions that could be improved by regular physical activity. Therefore, research in this age group is needed. DESIGN NARRATIVE: The Cooperative Lifestyle Intervention Program (CLIP) will test the effects of a physical activity intervention and a weight loss intervention on mobility disability of overweight or obese men and women who have evidence of cardiovascular disease or the metabolic syndrome. The public health relevance of the trial lies in the fact that the interventions will be delivered in conjunction with four Cooperative Extension Centers in counties surrounding Winston-Salem, North Carolina. CLIP will be designed as a three arm, randomized, controlled trial. The three 18-month treatments will include: (1) a basic health education-based control condition, (2) a group treatment program for physical activity, and (3) a lifestyle intervention designed to reduce sedentary behavior and promote weight loss. The primary aim will be to compare the effects of the three treatment arms on the change in performance on a 400-meter walk test over the course of 18 months. Secondary aims will include changes in cardiovascular risk factors, adiposity, cardiovascular fitness, physical activity, and health-related quality of life. Analyses will also be conducted to determine whether changes in the primary outcome are mediated by changes in constructs from social cognitive theory.

Conditions

• Cardiovascular Diseases
• Heart Diseases
• Metabolic Syndrome X
• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	Exercise	Increase Physical Activity to 150 min/wk
BEHAVIORAL	Weight Loss	Lose 7-10% of body weight and increase physical activity to 150 min/wk
BEHAVIORAL	Health Education Control	Lectures on information relevant to successful aging

Timeline

• Start date: 2005-08-01
• Primary completion: 2011-04-01
• Completion: 2011-04-01
• First posted: 2005-07-14
• Last updated: 2018-08-15

Locations

3 sites across 1 country: United States