NCT00102869

Dopaminergic Enhancement of Learning and Memory in Aphasia

Dopaminergic Enhancement of Learning and Memory (LL_001, Project on Aphasia)

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University Hospital Muenster · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.

Detailed description

Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether daily administration of levodopa, coupled with several hours of language training every day, will significantly improve naming abilities in patients with aphasia as compared to placebo administration. We furthermore examine with magnetic resonance imaging which brain regions need to be functionally intact for a dopaminergic improvement of language therapy.

Conditions

• Cerebrovascular Accident
• Aphasia

Interventions

Type	Name	Description
DRUG	levodopa	100mg levodopa per day over 10 days/ treatment phase

Timeline

• Start date: 2005-01-01
• Primary completion: 2007-02-01
• Completion: 2008-12-01
• First posted: 2005-02-04
• Last updated: 2013-10-07

Locations

1 site across 1 country: Germany