NCT00102232

Effect of Phosphatidylcholine on Plasma Homocysteine in Healthy Volunteers

Effect of Choline Supplemented as Phosphatidylcholine on Post-Methionine Loading and Fasting Concentrations of Plasma Homocysteine in Healthy Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (planned)
• Sponsor: Wageningen Centre for Food Sciences · Academic / Other
• Sex: Male
• Age: 50 Years – 71 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether supplementation with phosphatidylcholine lowers plasma homocysteine concentrations in healthy men.

Detailed description

A high homocysteine concentration is a potential risk for cardiovascular disease. Plasma homocysteine concentrations can be lowered through betaine supplementation. However, effects of choline supplementation, the precursor for betaine, on plasma homocysteine concentrations in healthy humans are unknown. If supplementation with choline or phosphatidylcholine, the form in which choline occurs in foods, lowers homocysteine concentrations, then extra intake of these compounds may lower cardiovascular disease risk in humans. Comparison: We compared the effects of supplementation with phosphatidylcholine to the effects of a placebo on fasting and post-methionine concentrations of plasma homocysteine in healthy men.

Conditions

• Healthy
• Cardiovascular Diseases

Interventions

Type	Name	Description
PROCEDURE	supplementation with phosphatidylcholine

Timeline

• Start date: 2003-05-01
• Completion: 2003-07-01
• First posted: 2005-01-26
• Last updated: 2005-06-24

Locations

2 sites across 1 country: Netherlands