NCT00075348

Genetic Study to Identify Gene Mutations in Participants Previously Enrolled in Clinical Trial NCI-99-C-0053 Who Have Von Hippel-Lindau Syndrome or Are at Risk for Von Hippel-Lindau Syndrome

Genetic Mutation Analysis In A VHL Population

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 260 (estimated)
• Sponsor: National Institutes of Health Clinical Center (CC) · NIH
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: The identification of gene mutations in individuals who have or are at risk for von Hippel-Lindau syndrome may allow doctors to better determine the genetic processes involved in the development of cancer. PURPOSE: This genetic study is finding gene mutations in participants with von Hippel-Lindau syndrome or who are at risk for developing von Hippel-Lindau syndrome.

Detailed description

OBJECTIVES: * Obtain laboratory identification and confirmation of research results for gene mutations in participants previously enrolled in NCI-99-C-0053 who have von Hippel-Lindau (VHL) syndrome or who are at risk for VHL syndrome. * Determine genotype status in these participants. OUTLINE: Participants submit a blood or buccal sample for genetic mutation analysis. Participants may receive genetic counseling and/or the results of genetic testing, if desired. PROJECTED ACCRUAL: A maximum of 260 participants will be accrued for this study.

Conditions

• Kidney Cancer
• Von Hippel-lindau Syndrome

Interventions

Type	Name	Description
GENETIC	mutation analysis

Timeline

• Start date: 2003-12-01
• Primary completion: 2008-12-01
• Completion: 2008-12-01
• First posted: 2004-01-12
• Last updated: 2012-03-15

Locations

1 site across 1 country: United States