NCT00066664

Serum Protein Patterns in Participants With Mycosis Fungoides/Cutaneous T-Cell Lymphoma, Psoriasis, or Normal Skin

Characterization of Serum Proteomic Patterns in Neoplastic and Inflammatory Skin Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 423 (estimated)
• Sponsor: National Institutes of Health Clinical Center (CC) · NIH
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

RATIONALE: The presence of specific serum proteins may allow a doctor to determine if a patient has mycosis fungoides/cutaneous T-cell lymphoma. PURPOSE: This clinical trial is studying how well blood protein analysis detects mycosis fungoides/cutaneous T-cell lymphoma.

Detailed description

OBJECTIVES: * Determine whether computer-assisted, higher-order analysis of participant low molecular weight serum proteins can detect distinctive proteomic patterns in participants with normal skin vs mycosis fungoides/cutaneous T-cell lymphoma vs psoriasis. * Determine whether these proteomic patterns can distinguish between various stages of cutaneous T-cell lymphoma. OUTLINE: This is a pilot study. Participants complete a general and skin health questionnaire and undergo a whole-body skin examination. Blood samples are taken and analyzed for low molecular weight serum proteins by mass spectroscopy. PROJECTED ACCRUAL: A total of 141-423 participants (47-94 each of healthy volunteers, psoriasis patients, and T3 cutaneous T-cell lymphoma patients and 141 T1, T2, and T4 mycosis fungoides patients) will be accrued for this study within 3 years.

Conditions

• Lymphoma

Interventions

Type	Name	Description
GENETIC	proteomic profiling

Timeline

• Start date: 2003-06-01
• Primary completion: 2007-12-01
• Completion: 2010-03-01
• First posted: 2003-08-07
• Last updated: 2012-03-15

Locations

4 sites across 1 country: United States