NCT00051402

Phytoestrogens and Memory Decline in Menopause

Phytoestrogens and Cognition in Menopause

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 96 (planned)
• Sponsor: National Center for Complementary and Integrative Health (NCCIH) · NIH
• Sex: Female
• Age: 62 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate whether soy-derived phytoestrogens taken as dietary supplements improve memory function in postmenopausal women who have experienced early memory decline.

Detailed description

Accumulating data has indicated that estrogens mediate enhancing effects on cognition and mood and may play a prophylactic role against age- and disease-related cognitive-cerebral decline. Phytoestrogens are plant-derived substances that have demonstrated estrogenic activity, but there is little prospective research regarding their effects on mental function. Mental health practitioners generally do not prescribe phytoestrogens. However, many women experiencing peri- and post-menopausal symptoms use marketed phytoestrogens under the perception of general health benefits, including presumably enhanced mental function. The purpose of this study is to develop preliminary data regarding the efficacy of isoflavone phytoestrogens in improving cognitive function in late middle-aged and elderly postmenopausal women with symptoms of memory impairment. Participants in this study will be randomized to receive either isoflavone supplementation or placebo. The study will last for 16 weeks, during which participants will take the supplement pill or placebo three times a day. Participants will be assessed at study entry and at Week 16 for changes in basal cortisol levels, mood, and neuropsychological measures of executive function ability and episodic memory.

Conditions

• Memory Loss
• Postmenopause

Interventions

Type	Name	Description
DRUG	Isoflavones

Timeline

• Start date: 2002-12-01
• Completion: 2007-08-01
• First posted: 2003-01-15
• Last updated: 2007-10-26

Locations

1 site across 1 country: United States