Trials / Terminated

TerminatedNCT00036855

Radiolabeled Monoclonal Antibody With or Without Peripheral Stem Cell Transplantation in Treating Children With Recurrent or Refractory Lymphoma

A Phase I Study Of Yttrium-Ibritumomab Tiuxetan (90Y Zevalin, Yttrium (90)-Anti-CD20, NSC # 710085) Preceded By Rituximab In Children With Recurrent/Refractory CD20 Positive Lymphoma

Status: Terminated
Phase: Phase 1
Study type: Interventional
Enrollment: 36 (actual)

Sponsor: National Cancer Institute (NCI) · NIH
Sex: All
Age: 21 Years
Healthy volunteers: Not accepted

Summary

Phase I trial to study the effectiveness of radiolabeled monoclonal antibody therapy with or without peripheral stem cell transplantation in treating patients who have recurrent or refractory lymphoma. Radiolabeled monoclonal antibodies can locate cancer cells and deliver radioactive tumor-killing substances to them without harming normal cells. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by anticancer therapy

Detailed description

OBJECTIVES: I. Determine the maximum tolerated dose (MTD) of yttrium Y 90 ibritumomab tiuxetan (IDEC-Y2B8) when preceded by rituximab in children with recurrent or refractory CD20-positive lymphoma for which no autologous peripheral blood stem cell transplantation (AuPBSCT) is planned. (Group A) If the dose-limiting toxicity (DLT) in group A is purely hematological, determine the MTD of IDEC-Y2B8 when combined with rituximab, AuPBSCT, and filgrastim (G-CSF) in a second group of children with recurrent or refractory CD20-positive lymphoma. (Group B) II. Determine the DLT of rituximab and IDEC-Y2B8 in these patients. III. Determine the dosimetry of indium In 111 ibritumomab tiuxetan preceded by rituximab in these patients. IV. Determine, preliminarily, the antitumor activity of rituximab and IDEC-Y2B8 in these patients. V. Assess the immune cell depletion (B-cell and T-cell) and recovery in patients treated with this regimen. VI. Determine the human anti-mouse antibody response in patients treated with this regimen. OUTLINE: This is a multicenter, dose-escalation study of yttrium Y 90 ibritumomab tiuxetan (IDEC-Y2B8). Patients are assigned to 1 of 2 groups. GROUP A (no planned peripheral blood stem cell \[PBSC\] support): Patients receive rituximab IV over 4-6 hours followed by indium In 111 ibritumomab tiuxetan (IDEC-In2B8) IV over 10 minutes on day 0 and undergo whole body imaging. Patients may then receive rituximab IV over 4-6 hours followed by IDEC-Y2B8 IV over 10 minutes on day 7. Cohorts of 3-6 patients in each subgroup (A1, A2, and A3) receive escalating doses of IDEC-Y2B8 until the maximum tolerated dose (MTD) is determined (subgroup A1 closed as of 10/8/04). The MTD is defined as the dose preceding that at which at least 2 of 3 or 2 of 6 patients experience dose-limiting toxicity (DLT). Some patients receive autologous PBSC IV over 30-60 minutes on day 35. GROUP B (planned PBSC support): Patients receive rituximab, IDEC-In2B8, and IDEC-Y2B8 as in group A. Patients also receive autologous PBSC IV over 30-60 minutes on day 21 and filgrastim (G-CSF) subcutaneously beginning on day 22 and continuing until blood counts recover or day 35. If the DLT in group A is purely hematological, cohorts of 3-6 patients in group B receive escalating doses of IDEC-Y2B8 until the MTD is determined. The MTD is defined as in group A. Patients in both groups are followed at days 63, 90, 180, 365, and then annually thereafter.

Conditions

Interventions

Type	Name	Description
BIOLOGICAL	rituximab	Given IV
RADIATION	indium In 111 ibritumomab tiuxetan	Given IV
RADIATION	yttrium Y 90 ibritumomab tiuxetan	Given IV
PROCEDURE	peripheral blood stem cell transplantation	Undergo PBSC transplantation
BIOLOGICAL	filgrastim	Given subcutaneously
OTHER	laboratory biomarker analysis	Correlative studies

Timeline

Start date: 2002-06-01
Primary completion: 2005-03-01
First posted: 2003-01-27
Last updated: 2013-01-17

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT00036855. Inclusion in this directory is not an endorsement.